Clinical Trials

Welcome to the AIDS Clinical Trials Unit at Case Western Reserve University / University Hospitals Case Medical Center (Case ACTU). For over 24 years the Case ACTU has been a worldwide leader in HIV/AIDS-related clinical research. This success has been possible because of the thousands of volunteers from Cleveland and Northeast Ohio who have taken part in our clinical trials.

The Case ACTU offers a wide variety of clinical trials for HIV-positive and HIV-negative people. New trials are regularly added to those being offered. Case ACTU staff members are available to talk with you about these trials.

Through its Community Advisory Board, other community partners and sponsored events, the Case ACTU offers many educational opportunities to learn more about HIV prevention, treatment and clinical research. If you have any questions, comments or would like to be added to our email newsletter list, please do not hesitate to contact us.

Title: A5391: Doravirine for Persons with Excessive Weight Gain while taking Integrase Inhibitors and Tenofovir Alafenamide (TAF): The DO-IT Study Click here for printable participant summary. Description: Weight gain after starting anti-HIV medicines is common, but recent studies have found that taking certain medicines may cause increased weight more than […]

A5391: Doravirine for Persons with Excessive Weight Gain on Integrase ...   Recently updated !

Title: A5386: Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control in the Reservoirs During Analytic Treatment Interruption Purpose: Researchers are looking for ways to get rid of HIV that rests hidden in areas of the body (reservoirs) where current […]

A5386, a clinical trial to control HIV in a new ...   Recently updated !

Title: A5379 BEEHIVE B-Enhancement of HBV Vaccination in Persons Living with HIV (BEe-HIVe) Description Hepatitis B is a serious viral infection that affects the liver and is transmitted through blood and body fluids. Although there is a vaccination for hepatitis B, sometimes the vaccines do not work well for people […]

A5379: BEEHIVE, a Hepatitis-B Vaccine Study for People Living with ...

Title: AIDS 392: TRAILBLAZER, elimination of CCR5 receptors with zinc finger to prevent viral replication, in participants living with HIV Purpose: The main purpose of this study is to test a new type of strategy to treat HIV: giving people living with HIV genetically modified versions of their own CD4+ […]

AIDS 392: TRAILBLAZER, elimination of CCR5 receptors with zinc finger ...

Protocol Summary: Trio (ACTG5377) is a Phase I, first-in-human, ascending-dose study of a tri-specific broadly neutralizing antibody, in participants living with HIV. This trial will look at a human-made antibody called SAR441236. Unlike the antibodies created by a person’s immune system that attach to HIV at one part, SAR441236 has […]

Trio A5377: A Phase I, first-in-human, ascending-dose study of a ...

Protocol Summary: This study will compare the use of long-acting, injectable anti-HIV medicines with anti-HIV medicines in daily pill form for people living with HIV who have not been previously adherent (keeping up) with their anti-HIV medicines in daily pill form. Purpose of This Study: Anti-HIV medicines taken as pills […]

Latitude A5359: To see if long-acting, injectable ARTs are helpful ...